김일철 교수
- Laboratory
- 기능유전체학 실험실 (Functional Genomics Lab.) (생물정보학)
- 연구실
- 자연대 1호관 428호, 419호
- 연락처
- 062-530-3407
- 이메일
- ickim@chonnam.ac.kr
세부내용
- 연구실원 (Fellow & Researchers, Doctoral Graduate Students, Masters-level Graduate Students, Undergraduate Students, Key Alumni)
- 최승현(Seung Hyun Choi)
- Doctorial Graduate student
- A field of research: bioethanol
- E-mail : moissa@naver.com
- 손민정(Min Jeong Son)
- Masters-level Graduate Graduate student
- A field of research: cancer
- E-mail : sommin7@nate.com
- 최승현(Seung Hyun Choi)
- 연구 분야 (RESEARCH INTERESTS)
The goal of functional genomics is to understand the relationship between an organism's genome and its phenotype. In our lab, the functions of genes involved in cancer, genetic diseases, or other malfunctions are studied by using microarray, NGS (next generation sequencing) analysis and high-throughput studies.
- 암 발생과정에서 driver mutation의 역할 규명
- 급성골수성백혈병(AML)을 대상으로 한 Whole exome sequencing
- Exome 서열분석 및 통합형 유전체 데이터베이스 구축
- AML에서 exome 서열분석을 통한 변이체의 발굴
- AML에서 변이체와 조혈계종양 환자의 clinical outcome의 associstion 분석
- 백혈병 진단 및 치료예후 판정 시 지표유전자로 적용
- 암 발생과정에서 유전자 발현 network 규명
- Transcriptional deregulation plays a critical role in the development of many cancers.
- Transcriptional deregulation include alterations in the e-x-p-r-e-s-s-i-o-n or structure of proteins that modulate transcription directly or through epigenetic modifications.
- In many cancers, the somatic mutations and the pathognomonic translocations involve genes that encode transcription factors.
- We are trying to understand a mechanism of how somatic mutations modifies the activity of these transcription factors and their participation in transcriptional networks.
- 암 발생과정에서 driver mutation의 역할 규명
- 연구 논문 (SELECTED PUBLICATIONS)
- Reduction of PDC1 e-x-p-r-e-s-s-i-o-n in S. cerevisiae with xylose isomerase on xylose medium. Kim DM, Choi SH, Ko BS, Jeong GY, Jang HB, Han JG, Jeong KH, Lee HY, Won Y, Kim IC. Bioprocess Biosyst Eng. (2012) 35:183-189.
- Raw starch fermentation to ethanol by an industrial distiller's yeast strain of Saccharomyces cerevisiae expressing glucoamylase and α-amylase genes. Kim HR, Im YK, Ko HM, Chin JE, Kim IC, Lee HB, Bai S. Biotechnol Lett. 2011 33(8):1643-1648.
- Enhancement of xylitol production by attenuation of intracellular xylitol dehydrogenase activity in Candida tropicalis. Byoung Sam Ko, Dong-Min Kim, Byoung Hoon Yoon, Suk Bai, Hyeon Yong Lee, Jung Hoe Kim, and Il-Chul Kim. Biotechnol Lett. 2011 Jun;33(6):1209-1213
- A functional promoter polymorphism of WNT10B is associated with abdominal fat in Korean female subjects. Il Chul Kim, Min Ho Cha, Jin Seok Moon, Dong Min Kim, Haeyong Lee, Kil Soo Kim and Yoosik Yoon. J Nutr Biochem. 2011, 22(3):252-258.
- Construction of a direct starch-fermenting industrial strain of Saccharomyces cerevisiae producing glucoamylase, alpha-amylase and debranching enzyme. Kim JH, Kim HR, Lim MH, Ko HM, Chin JE, Lee HB, Kim IC, Bai S. Biotechnol Lett. (2010) 32(5):713-719.
- Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory-secretory products of Clonorchis sinensis adult worms. Jung-Won Ju, Hyun-Na Joo, Myoung-Ro Lee, Shin-Hyeong Cho, Hyeng-Il Cheun, Jung-Yeon Kim, Young-Hee Lee, Kwang-Jun Lee, Woon-Mok Sohn, Dong-Min Kim, Il-Chul Kim, Byoung Chul Park, Tong-Soo Kim. Proteomics (2009) 9 : 3066-3078.
- 강의 (COURSES or COURSES TAUGHT)
- 학부
- 비교유전체학
- 생물정보학 및 실습
- 분자유전학실험
- 실험생화학
- 대학원
- 생물정보학
- 학부